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Reverse transcriptase-polymerase chain reaction demonstrated expression of amphiphysin in 8 of 10 small-cell lung carcinomas and in 5 of 14 breast carcinomas.These observations highlight the clinical and serological heterogeneity of paraneoplastic central nervous system disorders:Patients with a given clinical syndrome may have difference antineuronal antibodies,and patients with a given autoantibody specificity have differing clinical presentations. |
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